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 Applied
Neuroscience
Publications
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Applied
Neuroscience


MICRODIALYSIS ELECTRODE APPLICATIONS
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Methodology Spreading Depression
Neuropharmacology---- Epilepsy
Cerebral Ischaemia Long-Term Potentiation (LTP)

---BIOSENSOR TECHNOLOGY

Methodology 

Obrenovitch TP, Urenjak J, Zilkha E (1999) Microdialysis-based, multidisciplinary strategies in mice with genetic abnormalities. In Monitoring Molecules in Neuroscience 1999, Rollema H, Abercrombie E, Sulzer D, Zackheim J eds, S.U.N.Y., Stony Brook, p. 208-209.

Obrenovitch TP, Urenjak J, Zilkha E (1994) Intracerebral microdialysis combined with recording of extracellular field potential: A novel method for investigation of depolarizing drugs in vivo. Br J Pharmacol 113:1295-1302
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Obrenovitch TP, Richards DA, Sarna GS, Symon L (1993) Combined intracerebral microdialysis and electrophysiological recording: Methodology and applications. J Neurosci Meth 47:139-145

Neuropharmacology 

Urenjak J, Obrenovitch TP (2000) Kynurenine-3-hydroxylase inhibition in rats: effects on extracellular kynurenic acid concentration and N-methyl-D-aspartate-induced depolarisation in the striatum. J Neurochem 75:2427-2433
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Obrenovitch TP, Urenjak J (2000) In vivo assessment of kynurenate neuroprotective potency and quinolinate excitotoxicity. Amino Acids 19:299-309
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Urenjak TP, Obrenovitch TP (2000) Neuroprotective potency of kynurenic acid against excitotoxicity. Neuroreport 27:1341-1344
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Obrenovitch TP, Zilkha E, Urenjak J (1998) Effect of pharmacological inhibition of glutamate-uptake on ischemia-induced glutamate efflux and anoxic depolarization latency. Naunyn-Schmiedeberg's Arch Pharmacol 357:225-231
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Obrenovitch TP, Urenjak J, Zilkha E (1997) Effects of increased extracellular glutamate levels on the local field potential in the brain of anaesthetized rats. Br J Pharmacol 122:372-378
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Urenjak J, Zilkha E, Gotoh M, Obrenovitch TP (1997) Effect of acidotic challenges on local depolarizations evoked by N-methyl-D-aspartate (NMDA) in the rat striatum. Life Sci 61:523-535
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Obrenovitch TP, Hardy AM, Zilkha E (1997) Effects of L-701,324, a high-affinity antagonist of the N-methyl-D-aspartate (NMDA) receptor on the rat striatum electroencephalogram. Naunyn-Schmiedeberg's Arch Pharmacol 355:779-786
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Obrenovitch TP, Hardy AM, Urenjak J (1997) High extracellular glycine does not potentiate N-methyl-D-aspartate (NMDA)-evoked depolarization in vivo. Brain Res 746:190-194
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Urenjak J, Obrenovitch TP, Zilkha E (1996) Effect of probenecid on N-methyl-D-aspartate (NMDA) induced depolarizations in the rat striatum. Naunyn-Schmiedeberg's Arch Pharmacol 355:36-42
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Obrenovitch TP, Zilkha E (1996) Inhibition of cortical spreading depression by L-701,324, a novel antagonist at the glycine site of the N-methyl-D-aspartate receptor complex. Br J Pharmacol 117:931-937

Cerebral ischaemia 

Harris NG, Zilkha E, Houseman J, Symms MR, Obrenovitch TP, William SR (2000) The relationship between the apparent diffusion coefficient measured by magnetic resonance imaging, anoxic depolarisation and glutamate efflux during experimental cerebral ischemia. J Cereb Blood Flow Metab 20:28-36
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Shimizu-Sasamata M, Bosque-Hamilton P, Huang PL, Moskowitz MA, Lo EH (1998) Attenuated neurotransmitter release and spreading depression-like depolarizations after focal ischemia in mutant mice with disrupted type I nitric oxide synthase gene. J Neurosci 18:9564-9571

Taylor DL, Obrenovitch TP, Symon L (1996) Changes in extracellular acid-base homeostasis in cerebral ischaemia. Neurochem Res 21:1019-1028
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Obrenovitch TP (1996) Origins of glutamate release in ischaemia. Acta Neurochir Suppl (Wien) 66:50-55
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Wahl F, Obrenovitch TP, Hardy AM, Plotkine M, Boulu R, Symon L (1994) Extracellular glutamate during focal cerebral ischaemia in rats: Time course and calcium-dependency. J Neurochem 63:1003-1011
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Richards DA, Obrenovitch TP, A. Johonson-Mora, Symon L, Mase M. Curzon G (1993) Enhancement by previous potassium stimulation of the increases of striatal extracellular dopamine and 5-hydroxytryptamine during penumbral ischaemia. J Neurochem 61:2233-2238
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Richards DA, Obrenovitch TP, Johonson-Mora A, Islekel S, Symon L, Curzon G (1993) Effect of global ischaemia, under simulated penumbral conditions, on brain monoamine neurochemistry and subsequent neurological and histological deficits. J Neurochem 61:1801-1807
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Obrenovitch TP, Urenjak J, Richards DA, Ueda Y, Curzon G, Symon L (1993) Extracellular neuroactive amino acids in the rat brain striatum during moderate and severe transient ischemia. J Neurochem 61:178-186
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Richards DA, Obrenovitch TP, Symon L, Curzon G (1993) Extracellular dopamine and serotonin in the rat striatum during transient ischaemia of different severities: a microdialysis study. J Neurochem 60:128-136

Spreading depression 

Urenjak J, Obrenovitch TP (2000) Pharmacological investigation into the involvement of nitric oxide in K+-induced cortical spreading depression. Naunyn-Schmiedeberg's Arch Pharmacol 362:137-144
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Taylor DL, Urenjak J, Zilkha E, Obrenovitch TP (1997) Effects of probenecid on the elicitation of spreading depression in the rat striatum. Brain Res 764:117-125
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Obrenovitch TP, Zilkha E, Urenjak J (1996) Evidence against high extracellular glutamate directly promoting potassium-induced cortical spreading depression. J Cereb Blood Flow Metab 16:923-931
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Obrenovitch TP, Zilkha E (1996) Intracerebral microdialysis markedly inhibits the propagation of cortical spreading depression. Acta Neurochir Suppl (Wien) 67:21-23
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Obrenovitch TP, Zilkha E (1995) Changes in extracellular glutamate concentration associated with propagating cortical spreading depression. In Experimental headache models, Olesen J, Moskowitz MA eds, Raven Press, New York, p.113-117
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Obrenovitch TP, Zilkha E (1995) High extracellular potassium, and not extracellular glutamate, is required for the propagation of spreading depression. J Neurophysiol 73:2107-2114
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Taylor DA, Richards DA, Obrenovitch TP, Symon L (1994). Time course of changes in extracellular lactate evoked by transient K+-induced depolarisation in the rat striatum. J Neurochem 62:2368-2374
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Taylor DL, Davies SEC, Obrenovitch TP, Urenjak J, Richards DA, Clark JB, Symon L (1994) Extracellular N-acetyl-aspartate in the rat brain: In vivo determination of basal levels and changes evoked by high-K+. J Neurochem 62:2349-2355

Epilepsy 

Obrenovitch TP, Urenjak J, Zilkha E (1996) Evidence disputing the link between seizure activity and high extracellular glutamate. J Neurochem 66:2446-2454
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Millan MH, Obrenovitch TP, Sarna GS, Lok S-Y, Symon L, Meldrum BS (1991) Changes in rat brain extracellular glutamate concentration during seizures induced by systemic picrotoxin or focal bicuculline injection: an in vivo dialysis study with on-line enzymatic detection. Epilepsy Res 9:86-91

Long-term potentiation (LTP) 

Jay TM, Zilkha E, Obrenovitch TP (1999) Long-term potentiation in the dentate gyrus is not linked to increased extracellular glutamate concentration. J Neurophysiol 81:1741-1748


BIOSENSOR TECHNOLOGY 

Obrenovitch TP, Zilkha E (2001) Microdialysis coupled to on-line, enzymatic assays. Methods 23: 63-71.

Harris NG, Zilkha E, Houseman J, Symms MR, Obrenovitch TP, William SR (2000) The relationship between the apparent diffusion coefficient measured by magnetic resonance imaging, anoxic depolarisation and glutamate efflux during experimental cerebral ischemia. J Cereb Blood Flow Metab 20:28-36
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Jay TM, Zilkha E, Obrenovitch TP (1999) Long-term potentiation in the dentate gyrus is not linked to increased extracellular glutamate concentration. J Neurophysiol 81:1741-1748
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Obrenovitch TP, Zilkha E, Urenjak J (1998) Effect of pharmacological inhibition of glutamate-uptake on ischemia-induced glutamate efflux and anoxic depolarization latency. Naunyn-Schmiedeberg's Arch Pharmacol 357:225-231
-
Obrenovitch TP, Urenjak J, Zilkha E (1997) Effects of increased extracellular glutamate levels on the local field potential in the brain of anaesthetized rats. Br J Pharmacol 122:372-378
-
Obrenovitch TP, Zilkha E, Urenjak J (1996) Evidence against high extracellular glutamate promoting the elicitation of spreading depression. J Cereb Blood Flow Metab 16:923-931
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Obrenovitch TP, Urenjak J, Zilkha E (1996) Evidence disputing the link between seizure activity and high extracellular glutamate. J Neurochem 66:2446-2454
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Zilkha E, Obrenovitch TP, Koshi A, Kusakabe H, Bennetto HP (1995) Extracellular glutamate: on-line monitoring using microdialysis coupled to enzyme-amperometric analysis. J Neurosci Meth 60:1-9

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